Ismael “Mayo” Zambada, Co-Founder of Sinaloa Cartel, Set to Plead Guilty in the U.S.

Web Editor

August 25, 2025

a painting of a man with a stethoscope on his neck and a blue shirt on his shirt, David Alfaro Sique

Background and Relevance

Ismael “Mayo” Zambada, a 77-year-old Mexican, is one of the co-founders of the powerful Sinaloa cartel established in the 1980s. The cartel has been recognized as one of the most prolific and influential drug trafficking organizations globally. Zambada’s decision to plead guilty in a U.S. court signifies an important step in the ongoing efforts to dismantle the cartel’s operations.

Charges and Allegations

Zambada faces 17 charges, including running a continuing criminal enterprise, importing thousands of kilograms of cocaine and other narcotics like fentanyl, methylfentanil, heroin, and marijuana into the United States. He is also accused of money laundering, firearms offenses, and violent crimes associated with the cartel between 1989 and January 2024.

Under an agreement with the New York District Attorney’s office, which has taken over and unified another case in a Texas court, Zambada is expected to plead guilty to the main charges: continuing criminal enterprise and RICO conspiracy, a crime that penalizes agreements to commit organized criminal activities within a criminal group, according to U.S. Attorney Joseph Nocella’s letter.

Plea Hearing and Potential Sentence

Zambada plans to appear before Judge Brian Cogan for the guilty plea hearing at 12:00 PM (10:00 AM CDMX) in the Brooklyn court. Although the judge will determine Zambada’s sentence, it is anticipated to be less severe than that of his former partner Joaquín “Chapo” Guzmán, who is serving a life sentence following a lengthy trial in the same court and before the same judge.

The U.S. Attorney’s office announced earlier in August that it would not seek the death penalty, despite Zambada not being protected by a Mexican extradition agreement that excludes capital punishment.

Key Questions and Answers

  • Who is Ismael “Mayo” Zambada? A 77-year-old Mexican co-founder of the Sinaloa cartel, one of the most influential drug trafficking organizations globally.
  • What charges does Zambada face? He is accused of running a continuing criminal enterprise, importing large quantities of drugs into the U.S., money laundering, firearms offenses, and violent crimes associated with the cartel between 1989 and January 2024.
  • What is the significance of Zambada’s guilty plea? It marks an important step in dismantling the Sinaloa cartel’s operations and demonstrates the U.S.’s commitment to combating drug trafficking organizations.
  • What is the expected sentence for Zambada? While the judge will determine the sentence, it is anticipated to be less severe than Joaquín “Chapo” Guzmán’s life sentence.
  • Why is the Sinaloa cartel significant? It is considered one of the largest and most powerful drug trafficking organizations in the world, with operations spanning both sides of the U.S.-Mexico border.

Context and Broader Implications

Since his return to the White House in January, President Donald Trump has intensified threats against Mexico to curb drug trafficking, particularly fentanyl, which has caused tens of thousands of overdose deaths in the U.S.

In recent weeks, the U.S. government has deployed naval forces in the Caribbean to combat Latin American drug cartels, including the Sinaloa cartel and Venezuela’s Tren de Aragua, designated as global terrorist organizations by Washington.

In mid-August, Mexican authorities handed over 26 high-profile suspected drug traffickers to the U.S., adding to an earlier group of 29, including veteran capo Rafael Caro Quintero, accused of the 1985 murder of DEA agent Enrique “Kiki” Camarena.